The Working Group on Clinial Trials coordinated by the Ebola Response Anthropology Platform has produced a working document which considers the clinical trials that are planned as part of the Ebola outbreak response from a sociological and anthropological perspective. The document develops a series of critical and empirical questions to guide research that should be conducted within, alongside or separate from clinical interventions. The document goes on to consider questions specific to vaccine, therapeutic and convalescent blood and plasma trials.